The first fully 3-D-printed heart-on-a-chip

first_img <a href=”https://www.youtube.com/watch?v=KQBK4_byRvc” rel=”nofollow” target=”_blank”> <img src=”https://img.youtube.com/vi/KQBK4_byRvc/0.jpg” alt=”0″ title=”How To Choose The Correct Channel Type For Your Video Content ” /> </a> Harvard University researchers have made the first entirely 3-D-printed organ-on-a-chip with integrated sensing. Built by a fully automated, digital manufacturing procedure, the 3-D-printed heart-on-a-chip can be quickly fabricated and customized, allowing researchers to easily collect reliable data for short-term and long-term studies.This new approach to manufacturing may one day allow researchers to rapidly design organs-on-chips, also known as microphysiological systems, that match the properties of a specific disease or even an individual patient’s cells.The research is published in Nature Materials.3-D-printed heart-on-a-chip “This new programmable approach to building organs-on-chips not only allows us to easily change and customize the design of the system, but also drastically simplifies data acquisition,” said Johan Ulrik Lind, first author of the paper, postdoctoral fellow at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), and researcher at the Wyss Institute for Biologically Inspired Engineering at Harvard University.Organs-on-chips mimic the structure and function of native tissue and have emerged as a promising alternative to traditional animal testing. However, the fabrication and data collection process for organs-on-chips is expensive and laborious. Currently, these devices are built in cleanrooms using a complex, multistep lithographic process, and collecting data requires microscopy or high-speed cameras.“Our approach was to address these two challenges simultaneously via digital manufacturing,” said Travis Busbee, co-author of the paper and a graduate student in the lab of Jennifer Lewis, Hansjorg Wyss Professor of Biologically Inspired Engineering, core faculty member of the Wyss Institute, and co-author of the study. “By developing new printable inks for multimaterial 3-D printing, we were able to automate the fabrication process while increasing the complexity of the devices,” Busbee said.The researchers developed six different inks that integrated soft strain sensors within the microarchitecture of the tissue. In a single, continuous procedure, the team 3-D-printed those materials into a cardiac microphysiological device — a heart on a chip — with integrated sensors.“We are pushing the boundaries of three-dimensional printing by developing and integrating multiple functional materials within printed devices,” said Lewis. “This study is a powerful demonstration of how our platform can be used to create fully functional, instrumented chips for drug screening and disease modeling.”The chip contains multiple wells, each with separate tissues and integrated sensors, allowing researchers to study many engineered cardiac tissues at once. To demonstrate the efficacy of the device, the team performed drug studies and longer-term studies of gradual changes in the contractile stress of engineered cardiac tissues, which can occur over the course of several weeks.“Researchers are often left working in the dark when it comes to gradual changes that occur during cardiac tissue development and maturation because there has been a lack of easy, noninvasive ways to measure the tissue functional performance,” said Lind. “These integrated sensors allow researchers to continuously collect data while tissues mature and improve their contractility. Similarly, they will enable studies of gradual effects of chronic exposure to toxins.”“Translating microphysiological devices into truly valuable platforms for studying human health and disease requires that we address both data acquisition and manufacturing of our devices,” said Kit Parker, Tarr Family Professor of Bioengineering and Applied Physics at SEAS, who co-authored the study. Parker is also a core faculty member of the Wyss Institute. “This work offers new potential solutions to both of these central challenges.”To read the full story on the SEAS website.last_img read more

Harvest often

first_imgBy Sharon OmahenUniversity of GeorgiaThe key to helping your home garden produce more vegetables is topick, pick, pick. A University of Georgia horticulturist says themore often you harvest your crop, the more your garden willproduce.”If you want to make sure your garden plants keep producing, youhave to harvest your crops regularly,” said Bob Westerfield, aconsumer vegetable horticulturist with the UGA College ofAgricultural and Environmental Sciences. “If you stop picking,your plants will stop producing.”In your home garden, you must remember that the fruits of yourlabors are actually part of the plants’ reproductive cycle. “Ifyou don’t harvest your vegetables, your plants will shut down andstop producing,” he said. Best-tasting, tooHarvesting regularly will also ensure you are serving your familythe best-tasting vegetables.”Young squash, corn and cucumbers are much more flavorful thanlarger ones,” Westerfield said. “And if you leave vegetables likesquash on the vine too long they can become tough and chewy.”The success of some vegetables lies in where and how they wereplanted.”I get a lot of calls from home gardeners who want to know whytheir corn isn’t producing,” he said. “They’ll say they have along row of the prettiest corn plants you’ve ever seen, but nocorn.”Westerfield says the problem, in this case, lies in how the homegardener planted his corn. Plant more than one row”Corn is a wind-pollinated plant,” he said. “The tassels andsilks have to touch one another when the wind blows and theycan’t do that if they are planted in one long row.”He recommends planting three or four short rows instead.You can hurt your garden plants, too, by applying too muchinsecticide.”Most plants are pollinated by insects,” he said. “If you useinsecticidal sprays that knock out the insects, how are yourplants going to be pollinated?”For help with these and other home gardening issues, call yourlocal UGA Cooperative Extension agent at 1-800-ASK-UGA1 or visitthe Web at www.ugaextension.com.last_img read more

Government clamps down on planning delays

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BLOG: Governor Wolf Hosts Roundtables in Bethlehem and Scranton to Discuss the Current Opioid Crisis (Round-up)

first_img By: Eryn Spangler, Press Assistant Like Governor Tom Wolf on Facebook: Facebook.com/GovernorWolf The Morning Call: Gov. Wolf holds town hall on heroin epidemic in Bethlehem“There are a lot of things that we will disagree on in Harrisburg, as you all know,” said [Governor]Wolf….”But this is one of the issues that we all agree that we need to do something about.”Times-Tribune: Governor, local officials talk opioids at roundtableAt least 2,500 Pennsylvanians were among that number [in 2014], Mr. Wolf said, with numbers from 2015 expected to be higher. “It’s a chronic disease. It’s not something you can take a pill and be cured,” Mr. Wolf said. “It’s something that’s going to take some long-term care and long-term attention.”Lehigh Valley Live: Pennsylvania’s opioid and heroin fight comes to Bethlehem“This is not only an epidemic. At some of these roundtables, people have referred to this as a plague,” [Governor] Wolf said during the discussion hosted by Northampton Community College at the Fowler Family Southside Center.WNEP: Governor Talks Overdose Problem as Locals Plan Rally“A lot of it does start at home and I think the early diagnosis is really important,” said Governor Wolf. “If you see this, don’t ignore it and get out of denial. It’s a disease.”The Morning Call: Governor Tom Wolf Leads Round Table Talk (VIDEO) June 14, 2016 BLOG: Governor Wolf Hosts Roundtables in Bethlehem and Scranton to Discuss the Current Opioid Crisis (Round-up) Round-Up,  Substance Use Disorder,  The Blog Last week, Governor Wolf was joined by legislators, local officials, law enforcement, and health care professionals to continue his roundtable discussions regarding the current opioid crisis. The roundtables, held in Bethlehem and Scranton, provided a forum for participants to discuss statewide and local ideas on how to best combat the opioid and heroin abuse epidemic in Pennsylvania. Fighting the opioid and heroin epidemic is a top priority for Governor Wolf and his administration.“These roundtables are an opportunity to work collaboratively with the General Assembly and community leaders to ensure Pennsylvania leads the nation in the fight to combat the opioid abuse and heroin use crisis,” said Governor Wolf.The Wolf Administration hopes that these discussions are just the beginning of a larger conversation with both Republicans and Democrats in the House and Senate as well as local officials, law enforcement, emergency responders, and healthcare professionals.Take a look at the additional coverage below SHARE Email Facebook Twitterlast_img read more

Children’s Mashramani Dance Competition continues

first_imgStudents and teachers hailing from all 10 of the country’s administrative regions ventured to the National Cultural Centre on Thursday to participate in the annual Children’s Mashramani Dance Competition.The two-day event is being supported by ANSA McAL, which injected $1 million into the competition. The cheque was handed over at the commencement of theStudents of the Tapakuma Lake Primary School receiving their trophycompetition on Thursday.The much-anticipated competition saw the best performers from each of the 11 education districts vying for top honours. Hundreds of primary and secondary school students filled the theatre to show support for their respective schools or regions.Guyana Times caught up with the Administrator of the Education Ministry’s Allied Arts Department, Lorraine Barker-King after the first half of the event. She expressed that the necessary measures were taken so that the competition would run more smoothly and students would be able to go home earlier than previous years. Barker-King noted that they saw great performances from the younger students and were anticipating even better presentations from the students in the 11-13 and 14-17 categories.Among the winners Thursday were Westfield Prep (Georgetown); Uitvlugt Primary School (Region Three); and Tapakuma Lake Primary School (Region Two).The excitement will continue today (Friday) with the Calypso and Dramatic Poetry leg of the competition from 10:00h at the National Cultural Centre.Then the series of competitions will culminate on Saturday, February 17 with the grand float parade and costume competition. The parade will kick off at 10:00h sharp. The mini revellers will assemble at Parade Ground and then move east into Middle Street, north into Camp Street, east into Lamaha Street, north into Albert Street, then on to Thomas Lands to conclude at the National Park.last_img read more

What would you change about Letterkenny’s Market Square?

first_imgThe public is being invited to have their say on the future of Letterkenny’s Market Square at a consultation event next week.Letterkenny Chamber of Commerce is promoting a review of how the Market Square works as a public space and its potential use into the future as the focal point of the Main Street.On Friday 6th December, a consultation event will take place from 10am to 4.30pm right in the heart of the Main Street. The Letterkenny Chamber event is being facilitated by Donegal County Council and students from Queen’s University Belfast. Everyone is welcome to come along and discuss your ideas and help inform the future use and layout of the Square.All views and opinions on the future visions for the Square are welcome and will be reflected in the design brief for the proposed design competition. What would you change about Letterkenny’s Market Square? was last modified: November 28th, 2019 by Rachel McLaughlinShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)last_img read more

Ten games every Sharks fan should watch this season

first_imgSAN JOSE — The grind of a six-month regular season for the Sharks begins Wednesday at home against the Anaheim Ducks and let’s face it, only the most die-hard fans will be able to watch every period of all 82 games.And if we’re being honest, some games just stand out a bit more than others.To help sort everything out, here are 10 games this season that every Sharks fan should take time to watch.Oct. 3 vs. Anaheim Ducks, SAP Center — There’s nothing quite like opening night. Players get …last_img read more

Over 6 lakh Redmi Note 6 Pro units sold in first sale, Xiaomi announces next sale at 3PM today

first_imgYes. If you missed the first sale, that happened at 12PM today, Xiaomi is giving you another chance to grab the phone at a special price of Rs 12,499. The phone went out-of-stock soon after it went on sale at 12PM today on Flipkart and Mi.com. The company has now announced that the next sale of the Redmi Note 6 Pro will happen at 3PM today. Similar to the 12PM sale, during the 3PM sale too, the Redmi Note 6 Pro will be available for special price of Rs 12,499.Update 3: The second sale is also over and the next two sales are also today. They are at 6PM and 9PM, on Flipkart and Mi.com. During these two sales also, the smartphone will be available for Black Friday sale price, which is Rs 12,999.Update 2: Manu Jain has posted the tweet again and yes, the company has actually sold 6 lakh units in its first flash sale today. Considering the demand of the phone, we expect the same numbers in the second sale as well.Update 1: There is something interesting about the Redmi Note 6 Pro Sale today. Around 1PM, Xiaomi India chief Manu Jain shared on Twitter that 600000 units of the Redmi Note 6 Pro were sold in today’s flash sale. But within minutes the tweet was deleted, which was weird so either there was something odd about the number he shared. Or may be 6 lakh units of the Redmi Note 6 Pro are on sale today in two flash sales and Xiaomi expects all of them to be sold out after its second sale at 3pm.advertisementAs a part of the Black Friday sale, Xiaomi has announced to sell the Redmi Note 6 Pro for a lower price tag of Rs 12,999. This price is set for the 4GB RAM/64GB storage model. During the same Black Friday sale, the 6GB RAM model of the phone will be available for Rs 14,999. On top of the flat Rs 1,000 discount, Xiaomi has also partnered with HDFC Bank to offer buyers with Rs 500 additional instant discount. After all the discounts, the interested customers can get the Redmi Note 6 Pro 4GB RAM for Rs 12,499, while the 6GB RAM model for Rs 14,499.All the four colour variants of the Redmi Note 6 Pro including the Red, Blue, Black and Rose Gold will be available during the sale. As for the MRP of the phone, in India, the base model of the Redmi Note 6 Pro with 4GB RAM and 64GB of internal storage has been priced at Rs 13,999, while the top-end model with 6GB RAM and 64GB storage comes for Rs 15,999. The storage of both the phones is expandable by a microSD card up to 256GB. So, if you’re interested to buy the Redmi Note 6 Pro, today is the best time to get it, and the phone will be available for the lowest ever price.To get the phone before it goes out-of-stock again, buyers should ensure to log in to Flipkart or Mi.com before 3 PM, when the sale is set to start. They should add all their personal details including their name, delivery address, card details and others to book the phone quickly.The Redmi Note 6 Pro is the first Xiaomi to come with four camera setup. On the rear panel, the phone includes a dual camera system. It comes with a primary sensor of 12-megapixel with Dual Pixel autofocus and f/1.9 aperture and a secondary sensor of 5-megapixel for depth sensing. While on the front, the Redmi Note 6 Pro includes a primary sensor of 20-megapixel and a secondary camera with a 2-megapixel sensor for portrait selfies.ALSO READ: Redmi Note 6 Pro review: Phone with best camera performance under Rs 20,000This is also the first Note from Xiaomi to come with a notched display. The notch equips the two selfie cameras, sensors and earpiece. Not just that, the Redmi Note 6 Pro is also the first phone from Xiaomi to come with Android 8.1 Oreo-based MIUI 10 out-of-the-box. As for the specs, the Redmi Note 6 Pro sports a 6.26-inch Full HD+ IPS LCD display with an aspect ratio of 19:9. It is also powered by a 1.8GHz octa-core Qualcomm Snapdragon 636 processor paired with Adreno 509 GPU paired with up to 6GB RAM and 64GB storage.last_img read more

How Often Do College Football Teams Finish No 1 Then Start At

In January, Florida State beat Auburn in the last-ever BCS National Championship Game, capping an undefeated season that earned it the No. 1 ranking in the final Associated Press poll. Seven months later, the Seminoles are atop the college football world, ranked No. 1 in the AP’s preseason top 25 poll. How rare is it for the defending champs to return to No. 1 the following preseason? And how has that rate changed over time?Since 1950, defending No. 1s have begun the following season atop the polls 23 times, or once every 2.8 years. Four of the last six preseason No. 1s were defending champions — although before that, it only happened three times in 12 years, and seven times in 33 years. On average, the top team in the AP’s preseason poll checked in at No. 3.1 in the final poll taken after the previous season.Top preseason teams have gone on to win the championship 10 times in the 65 seasons since 1950, or 15 percent of the time. The last preseason No. 1 to finish the season No. 1 was Southern California in 2004. read more

Pueblo Chemical Depot Reuse Plan Focuses on Manufacturing Logistics Storage

first_img Dan Cohen AUTHOR Almost half of the 15,850 acres the LRA for the Pueblo Chemical Depot is responsible for developing would be devoted to industrial uses, including manufacturing, distribution and warehousing, under the draft redevelopment plan released for the central Colorado site last month.Other primary uses would include R&D, education, agricultural research, renewable energy production and open space. Industrial uses would take advantage of the depot’s central location, existing road and rail networks, and its 600-plus storage igloos.“This is where the fun part begins,” PuebloPlex CEO and President Russell DeSalvo said at a public meeting. “This has the potential over time to expand our real estate base, our economy and our property tax base,” DeSalvo said, reported the Pueblo Chieftain.Officials outlined a variety of possible uses for the site that would fit with the draft plan:a business park, with a truck plaza, hotels and shops;a storage and maintenance depot for rail cars;a training facility for law enforcement;manufacturing plants;solar arrays and wind turbines;a research center for hemp or marijuana; andstorage facilities for residents or industry.At the same time, they stressed the ultimate uses for the depot could change dramatically, given the size of the property and the possibility of new technologies.“This is one of the largest redevelopment projects in the United States,” said Celeste Warner, vice president and director of planning for Matrix Design Group, which prepared the reuse plan. “The key is to remain flexible.”In addition to the acreage DOD already has declared surplus, the LRA likely will gain control of the remaining 7,000 acres at the depot now being used to destroy the nation’s chemical weapons stockpile.“The buildout wouldn’t occur for 100 years,” Warner said.One key hurdle to implementing the reuse plan is the aging infrastructure at the 74-year-old depot targeted for closure in 1988, according to the story. The plan’s success also depends on the construction of a new interchange at U.S. 50 providing access to PuebloPlex.last_img read more

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